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Updated: Apr 9, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
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Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

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数据驱动的AML表型剖析揭示了与预后相关的原生类细胞

Jacob H Levine1, Erin F Simonds2, Sean C Bendall3

  • 1Departments of Biological Sciences and Systems Biology, Columbia University, New York, NY 10027, USA.

Cell
|June 23, 2015
PubMed
概括

这项研究引入了PhenoGraph,一种用于分析急性髓性白血病 (AML) 细胞多样性的新方法. 它揭示了细胞表面的外观并不总是与内部功能相匹配,改善了AML患者的生存预测.

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Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
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