用固酶5型抑制剂治疗勃起功能障碍和恶性黑色素瘤风险
Stacy Loeb1, Yasin Folkvaljon2, Mats Lambe3
1Department of Urology, Population Health, and Laura and Isaac Perlmutter Cancer Center, New York University, New York.
JAMA
|June 24, 2015
概括
用于勃起功能障碍的固酶5型 (PDE5) 抑制剂与男性恶性黑色素瘤风险的适度增加有关. 这种关联在单个处方中最强,质疑因果关系.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学 是一个学科.
- 流行病学 流行病学
背景情况:
- 固酶5型 (PDE5) 抑制剂是治疗勃起功能障碍的口服药物.
- PDE5通路与恶性黑色素瘤的发展有关.
- 以前的报道表明,在西尔德纳菲尔使用者中,黑色素瘤风险增加.
研究的目的:
- 调查PDE5抑制剂使用与黑色素瘤风险之间的关联.
- 根据特定的PDE5抑制剂,处方数和黑色素瘤阶段来分析风险.
主要方法:
- 在瑞典进行了一项全国性的,基于人口的,嵌套的病例控制研究.
- 数据来源于瑞典卫生登记册,包括4065例黑色素瘤病例 (2006-2012) 和根据出生年份匹配的对照.
- 暴露量是根据填写的西尔德纳菲尔,瓦尔德纳菲尔或塔达拉菲尔处方来定义的.
主要成果:
- 使用PDE5抑制剂的男性显示黑色素瘤风险增加 (OR,1.21).
- 最高的风险与单一处方有关 (OR,1.32),多处方没有显著增加.
- 使用PDE5抑制剂与早期黑色素瘤 (阶段0和I) 和基底细胞癌有关.
结论:
- 在男性中使用PDE5抑制剂与恶性黑色素瘤风险的适度,统计学上显著增加有关.
- 观察到的模式,特别是缺乏与多个处方的关联,引发了关于因果关系的问题.
- 需要进一步的研究来澄清PDE5抑制剂和黑色素瘤之间的关系.
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