循环节律. 循环节律. 一个蛋白质折叠开关与昼夜振荡器连接到蓝藻细菌的时钟输出
Yong-Gang Chang1, Susan E Cohen2, Connie Phong3
1School of Natural Sciences, University of California, Merced, CA 95343, USA.
概括
蓝藻细菌是一种蓝藻细菌.
科学领域:
- 微生物学 微生物学
- 生物化学 生物化学
- 分子生物学分子生物学
背景情况:
- 循环时钟以24小时的节律调节生物活动.
- 菌利用三种蛋白质振荡器 (KaiA,KaiB,KaiC) 作为它们的昼夜钟.
- 这种振荡器会产生 KaiC 酸化的昼夜节律.
研究的目的:
- 阐明蓝藻细菌昼夜钟实现精确计时的机制.
- 调查KaiB蛋白动态在昼夜节律调节中的作用.
- 了解振荡器的计时和信号功能之间的联系.
主要方法:
- 对KaiB蛋白的结构分析.
- 生物化学测试用于研究蛋白质与蛋白质相互作用.
- 对昼夜节律相位过渡的分析.
主要成果:
- KaiB蛋白在两个截然不同的3D折叠之间表现出一种罕见的过渡.
- 这种过渡引入了一个时间延迟,这对于同步振荡器与地球旋转至关重要.
- 在折叠切换时,KaiB与KaiC和KaiA相互作用,触发相位过渡并调节时钟输出路径.
结论:
- KaiB的形状灵活性是生物钟定时的关键决定因素.
- 该KaiB折叠交换机制提供了一个关键的时间延迟,为昼夜带动.
- 这项研究揭示了蓝藻细菌时钟如何将计时与细胞信号联系起来.
相关概念视频
Circadian Rhythms and Gene Regulation
4.7K
The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
4.7K
Circadian Rhythms and Gene Regulation
2.5K
2.5K
Biological Clocks and Seasonal Responses
42.1K
The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
42.1K
Bacterial Phylum Cyanobacteria
876
Cyanobacteria are a diverse group of oxygenic, phototrophic bacteria that played a pivotal role in converting Earth’s atmosphere from anoxic to oxygen-rich billions of years ago. They exhibit remarkable morphological diversity, ranging from unicellular forms to filamentous types, with cell sizes varying between 0.5 μm and 100 μm. Cyanobacteria are classified into five groups: Chroococcales (unicellular, dividing by binary fission), Pleurocapsales (unicellular, dividing by...
876
Prokaryotic Transcriptional Activators and Repressors
27.0K
The organization of prokaryotic genes in their genome is notably different from that of eukaryotes. Prokaryotic genes are organized, such that the genes for proteins involved in the same biochemical process or function are located together in groups. This group of genes, along with their regulatory elements, are collectively known as an operon. The functional genes in an operon are transcribed together to give a single strand of mRNA known as polycistronic mRNA.
Transcription of prokaryotic...
Transcription of prokaryotic...
27.0K
Prokaryotic Transcriptional Activators and Repressors
12.0K
12.0K


