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登革热亚基因组RNA与TRIM25结合,以抑制干扰素表达,以达到流行病学适应性

Gayathri Manokaran1, Esteban Finol2, Chunling Wang3

  • 1Program in Emerging Infectious Diseases, Duke-National University of Singapore Graduate Medical School, Singapore. Defence Medical and Environmental Research Institute, DSO National Laboratories, Singapore. Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Science (New York, N.Y.)
|July 4, 2015
PubMed
概括

一种新的登革热病毒 (DENV) 菌株 (PR-2B DENV-2) 通过产生更多亚基因组病毒RNA (sfRNA) 来增加其流行潜力. 这种sfRNA逃避了宿主免疫反应,增强了病毒的健康状况.

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