大脑的结构. 皮层折叠尺度普遍与表面积和厚度有关,而不是神经元的数量
Bruno Mota1, Suzana Herculano-Houzel2
1Instituto de Física, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
概括
皮层折叠,塑造大脑的大脑的过程,通过物理模型来解释. 这个模型统一了跨物种和个体的大脑折叠,将表面积和厚度与折叠模式联系起来.
科学领域:
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
- 生物物理学的生物物理.
背景情况:
- 较大的大脑表现出皮层折叠的增加,这种现象对认知功能至关重要.
- 然而,驱动皮层折叠的潜在机制在很大程度上是未知的.
- 了解皮层折叠是理解大脑进化和发育障碍的关键.
研究的目的:
- 阐明控制皮层折叠程度的生物物理原理.
- 为了建立大脑大小,皮质几何和折叠模式之间的定量关系.
- 探索对进化发育生物学和神经病理学的影响.
主要方法:
- 开发了一个基于最小化与皮层形状相关的自由能量的物理模型.
- 将已知的轴突延长机制纳入生物物理模型.
- 通过将其预测与跨物种和个体观察到的皮层折叠进行比较来验证模型.
主要成果:
- 在lissencephalic和gyrencephalic物种中显示出皮层折叠的统一缩放关系.
- 显示皮层折叠尺度与皮层表面积和皮层厚度的平方根的乘积.
- 物理模型准确地预测了折纸球的折叠指数,这表明了普遍的原则.
结论:
- 皮层折叠是由与轴突生长和表面张力相关的基本物理原理所支配的.
- 通过这种模型解释的光脑 (光滑皮层) 和旋脑 (折叠皮层) 之间存在连续性.
- 这些发现提供了对大脑复杂性的进化起源和轻脑症的病因学的见解.
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