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A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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通过GPCRs激活Gα的通用全oster机制

Tilman Flock1, Charles N J Ravarani1, Dawei Sun2,3

  • 1MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|July 7, 2015
PubMed
概括

G蛋白结合受体 (GPCRs) 通过一种保存的全机制激活G蛋白. 这种保存的G蛋白激活机制允许GPCRs快速多样化,同时保持信号特异性.

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