在分子结节和链接的中央腔内强有力的和选择性的阴离子结合
Jean-François Ayme1, Jonathon E Beves1, Christopher J Campbell1
1School of Chemistry, University of Manchester, Oxford Road, Manchester M13 9PL, United Kingdom.
Journal of the American Chemical Society
|July 8, 2015
概括
化学家们创造了复杂的分子结和聚烯,它们强烈结合化离子. 这些合成宿主表现出异常高的结合亲和力,与银盐对化离子的结合亲和力相美.
科学领域:
- 超分子化学 超分子化学
- 有机化学 有机化学
- 材料科学 材料科学 材料科学
背景情况:
- 超分子化学侧重于通过非共价相互作用保持在一起的复杂化学系统的研究.
- 开发具有对特定离子的高结合亲和度的合成宿主对于传感和分离中的应用至关重要.
研究的目的:
- 合成和表征新的拓复杂分子,特别是分子五叶结和 [2]catenanes.
- 为了研究这些复杂的分子架构的离子结合能力.
主要方法:
- 合成圆形Fe(II) 双螺旋体支架的合成.
- 构建分子五叶结和 [2]catenane 结构.
- 在乙尼中使用滴定和光谱等技术进行离子结合研究.
主要成果:
- 成功合成了分子五叶子结和双重/三重交织 [2]链.
- 证明了这些宿主中心腔内化离子的强度结合.
- 达到了极高的结合常量,高达 (3.6 ± 0.2) × 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 11 11 11 11 11 11 对于化物来说,可以与银盐相比较.
结论:
- 拓复杂的宿主分子可以表现出显著的离子结合亲和力.
- 静电和CH···X(-) 结相互作用是观察到的强结合的关键.
- 这些发现为设计用于离子识别的先进合成受体开辟了道路.
更多相关视频
10:33Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
Published on: October 26, 2015
11.9K
08:33Measuring Nucleotide Binding to Intact, Functional Membrane Proteins in Real Time
Published on: March 11, 2021
2.4K
相关概念视频
Ligand Binding Sites
15.8K
Proteins are dynamic macromolecules that carry out a wide variety of essential processes; however, the activities of most proteins depend on their interactions with other molecules or ions, known as ligands.
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
Protein-ligand interactions are quite specific; even though numerous potential ligands surround a cellular protein at any given time, only a particular ligand can bind to that protein. Moreover, a ligand binds only to a dedicated area on the surface of the protein, known as the...
15.8K
Drug-Receptor Bonds
5.4K
Drug-receptor bonds are formed through various chemical forces when drugs interact with target cells. Covalent bonds, strong and irreversible, are exemplified by DNA-alkylating anticancer agents that inhibit cell division. However, such irreversible drug binding lacks selectivity and can modify the DNA of the surrounding healthy cells. Covalent binding often contributes to tissue toxicity, as seen with chloroform and paracetamol metabolites binding to the liver, causing hepatotoxicity.
In...
In...
5.4K
Valence Bond Theory
11.7K
Coordination compounds and complexes exhibit different colors, geometries, and magnetic behavior, depending on the metal atom/ion and ligands from which they are composed. In an attempt to explain the bonding and structure of coordination complexes, Linus Pauling proposed the valence bond theory, or VBT, using the concepts of hybridization and the overlapping of the atomic orbitals. According to VBT, the central metal atom or ion (Lewis acid) hybridizes to provide empty orbitals of suitable...
11.7K
Valence Bond Theory
51.6K
Overview of Valence Bond Theory
51.6K
Metal-Ligand Bonds
25.6K
The hemoglobin in the blood, the chlorophyll in green plants, vitamin B-12, and the catalyst used in the manufacture of polyethylene all contain coordination compounds. Ions of the metals, especially the transition metals, are likely to form complexes.
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
In these complexes, transition metals form coordinate covalent bonds, a kind of Lewis acid-base interaction in which both of the electrons in the bond are contributed by a donor (Lewis base) to an electron acceptor (Lewis acid). The Lewis acid in...
25.6K
Complexation Equilibria: The Chelate Effect
1.6K
In complexation reactions, metal atoms or cations interact with ligands to form donor-acceptor adducts called metal complexes. Ligands that bind through one donor site are monodentate, ligands with two donor sites are bidentate, and those with more than two donor sites are polydentate ligands. For example, ethylene diamine is a bidentate ligand that binds through two nitrogen donor atoms, forming a five-membered ring. EDTA is a polydentate ligand that binds through four oxygen and two nitrogen...
1.6K
