粘膜免疫学 粘膜免疫学 微生物群通过RORγt+ T细胞调节2型免疫
Caspar Ohnmacht1, Joo-Hong Park1, Sascha Cording1
1Institut Pasteur, Microenvironment and Immunity Unit, 75724 Paris, France.
概括
早期的肠道微生物群塑造了免疫反应. 微生物群诱导的调节性T细胞 (Tregs) 表达RORγt平衡2型免疫,预防过敏炎症并增强对虫的防御能力.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 过敏和炎症的发生
背景情况:
- 生命早期的共生微生物群变化会导致2型免疫力升高和过敏性炎症.
- 微生物群调节2型免疫的确切机制尚不完全理解.
- 已知肠道微生物群诱导肠道中的T辅助细胞17 (T(H) 17和调节性T细胞 (T(regs)).
研究的目的:
- 研究微生物群诱导的调节性T细胞 (Tregs) 在调节2型免疫力中的作用.
- 阐明微生物群诱导的Tregs的分化途径及其与T(H) 17细胞的关系.
- 了解RORγt表达Tregs如何影响对虫和过敏病理的免疫反应.
主要方法:
- 分析T细胞分化的途径在微生物群信号的存在和缺乏.
- 研究核激素受体RORγt在微生物体诱导的T(regs) 中的表达.
- 评估RORγt (+) T (regs) 对T (H) 2驱动的免疫反应和虫防御的影响.
主要成果:
- 发现微生物群诱导的T ((regs) 表达了核激素受体RORγt.
- 这些由微生物诱导的T (H) 17细胞沿着一条也产生T (H) 17细胞的途径分化.
- 缺少RORγt (+) T (regs) 导致了更有效的T (H) 2介导的对虫的防御,但加剧了T (H) 2相关的病理.
结论:
- 肠道微生物群通过诱导表达RORγt的T (regs) 和T (H) 17细胞来调节2型免疫反应.
- 微生物群诱导的3型RORγt ((+) T ((regs) 在平衡粘膜体免疫反应方面发挥着至关重要的作用.
- 这些发现凸显了微生物群在预防过敏炎症和维持免疫平衡中的重要性.
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