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由素-泛素诱导的帕金激活的机制

Tobias Wauer1, Michal Simicek1, Alexander Schubert1

  • 1Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Nature
|July 11, 2015
PubMed
概括

帕金结合酸化无素的晶体结构揭示了突变如何导致帕金森症. 这一发现解释了PARKIN的激活,并为该疾病提出了新的治疗点.

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