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小细胞肺癌的综合基因组资料

Julie George1, Jing Shan Lim2, Se Jin Jang3

  • 1Department of Translational Genomics, Center of Integrated Oncology Cologne-Bonn, Medical Faculty, University of Cologne, 50931 Cologne, Germany.

Nature
|July 14, 2015
PubMed
概括

110例小细胞肺癌 (SCLC) 的基因组测序揭示了TP53和RB1瘤抑制剂的强制性损失. 这项研究确定了新的致癌驱动因素和治疗点,包括NOTCH途径突变,为这种致命的癌症提供了希望.

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