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在D374Y-PCSK9高胆固醇小猪中诱导持续的流动干扰加快了动脉生成并促进了细纤维肌瘤的发展

Ryan M Pedrigi1, Christian Bo Poulsen1, Vikram V Mehta1

  • 1From Department of Bioengineering, Imperial College London, United Kingdom (R.M.P., V.V.M., A.L.P., R.K.); Institute of Clinical Medicine, Aarhus University Hospital, Denmark (C.B.P., N.R.H., M.M.B., N.P.A., A.K.G., J.F.B., E.F.); Department of Cardiology, Aarhus University Hospital, Denmark (C.B.P., N.R.H., M.M.B., N.P.A., A.K.G., J.F.B., H.E.B., E.F.); NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (I.D.K., W.A.S.B., G.D.'A., A.M., C.D.M., R.d.S.); Graduate Medical School, Duke-National University of Singapore, Singapore (E.P.); National Heart Centre, NHRIS, Singapore (N.F.); National Heart and Lung Institute, Imperial College London, United Kingdom (C.D.M., R.d.S.); and Institute of Cardiovascular Medicine and Science, Royal Brompton and Harefield NHS Foundation Trust, London, United Kingdom (C.D.M., R.d.S.).

Circulation
|July 17, 2015
PubMed
概括

血流干扰,特别是低或多向剪切应力,导致晚期冠状动脉硬化斑块的发展. 持续低剪压是形成薄盖纤维肌瘤的关键,

关键词:
动脉样硬化生物物理细胞内膜血液动力学斑块,动脉样硬化剪切应力断层扫描,光学一致性

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