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相关概念视频

Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
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Mechanism of Ciliary Motion01:05

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Aromatic Hydrocarbon Cations: Structural Overview01:18

Aromatic Hydrocarbon Cations: Structural Overview

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Cycloheptatriene is a neutral monocyclic unsaturated hydrocarbon that consists of an odd number of carbon atoms and an intervening sp3 carbon in the ring. The three double bonds in the ring correspond to 6 π electrons, which is a Huckel number, and therefore satisfies the criteria of 4n + 2 π electrons. However, the intervening sp3 carbon disrupts the continuous overlap of p orbitals. As a result, cycloheptatriene is not aromatic.
Removing one hydrogen from the intervening CH2 group...
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Tension Response at Adherens Junctions01:26

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The adherens junctions that anchor cells together are multi-protein complexes that dynamically adapt to mechanical stimuli such as tensile forces and shear stress. Mechanosensory proteins in these junctions can sense such mechanical stimuli and undergo a shift in their conformation, resulting in an altered function — a process called mechanotransduction.
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Catenins01:23

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Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
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Chair Conformation of Cyclohexane02:02

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The chair conformation is the most stable form of cyclohexane due to the absence of angle and torsional strain. The absence of angle strain is a result of cyclohexane’s bond angle being very close to the ideal tetrahedral bond angle of 109.5° in its chair conformer. Similarly, the torsional strain is also absent owing to the perfectly staggered arrangement of bonds.
The hydrogen atoms linked to carbons are arranged in two different axial and equatorial orientations to achieve this...
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High-Contrast and Fast Photorheological Switching of a Twist-Bend Nematic Liquid Crystal
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在多元中逐步运动 [2]

Zheng Meng1,2, Ying Han1, Li-Na Wang3

  • 1†Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

Journal of the American Chemical Society
|July 18, 2015
PubMed
概括
此摘要是机器生成的。

研究人员开发了一种新型的三重互锁链. 这种分子机器表现出由酸变化引发的阶段性运动, 提供了对生物分子机器机制的洞察.

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科学领域:

  • 超分子化学
  • 化学工程
  • 生物分子工程

背景情况:

  • 生物分子机器通过涉及形状变化的多步骤过程运行.
  • 了解这些复杂的运动对于设计人工分子机器至关重要.

研究的目的:

  • 报告一个新的三重互锁 [2](3) catenane.
  • 为了研究这种酸触发运动的步骤.
  • 阐明分子机器的结构变化和动力学.

主要方法:

  • 一个新的三重互锁 [2](3) 宿主-客户系统的合成.
  • 使用酸定位来触发和量化逐步运动.
  • 直接识别和定量稳定的形状状态.
  • 确定解离常数 (pKa) 值以表征动态.

主要成果:

  • 合成的 [1] [2] [3] 氨酸表现出一个循序渐进的酸触发运动.
  • 确定并量化了四个稳定的构造状态,证实了多步骤的过程.
  • 确定pKa值,量化环境酸度的动态.
  • 对于特定的客位的宿主环的选择性运动.

结论:

  • 这项研究成功地展示了复杂分子机器的步骤运动.
  • 这些发现为复杂的生物分子机器提供了洞察力.
  • 这项研究为设计具有先进机械化学特性的人造分子机器提供了基础.