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Updated: Apr 6, 2026

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在Ser571处的电压通酸化调节晚期电流,心律失常和活体心脏功能

Patric Glynn1, Hassan Musa1, Xiangqiong Wu1

  • 1From Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Wexner Medical Center, Columbus (P.G., H.M., X.W., S.D.U., S.L., L.Q., P.J.W., P.B.R., S.G., P.J.M., T.J.H.); Department of Biomedical Engineering, College of Engineering, The Ohio State University, Columbus (P.G., X.W., S.D.U., L.Q., T.J.H.); Departments of Physiology & Cell Biology (H.M., S.L., P.J.W., P.B.R., S.G., P.J.M.) and Internal Medicine (P.J.M., T.J.H.), The Ohio State University Wexner Medical Center, Columbus; and Division of Pharmacy Practice and Administration, College of Pharmacy, The Ohio State University, Columbus (P.B.R.).

Circulation
|July 19, 2015
PubMed
概括

这项研究表明,Nav1.5通道中的Ser571对晚期电流 (INa,L) 至关重要,并促进心律失常. 这一发现为CaMKII依赖的INA,L激活和潜在的治疗点提供了洞察力.

关键词:
Na+ 电流目前的情况.行动潜力 行动潜力 行动潜力心律不整,心脏节律失常,心脏病.类型 2 的依赖-卡尔莫杜林蛋白蛋白激酶.离子通道 离子通道

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