从动态组合图书馆引发的自我复制器的出现
Piotr Nowak1, Mathieu Colomb-Delsuc1, Sijbren Otto1
1Centre for Systems Chemistry, Stratingh Insitute, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Journal of the American Chemical Society
|July 21, 2015
概括
模板通过增加分子度超过关键聚合度,使其能够在动态组合库中自我复制. 一旦启动,自我复制继续没有模板.
科学领域:
- 化学学
- 生物化学
- 系统化学
背景情况:
- 动态组合图书馆 (DCL) 是可逆相互作用的分子系统.
- 自复制需要一个分子的度超过它的临界聚合度 (CAC).
- 之前的DCL研究尚未完全解决自我复制的启动问题.
研究的目的:
- 调查模板添加如何在DCL中启动自我复制.
- 证明模板诱导的复合物可以超越CAC值.
- 证明已启动的自我复制可以独立于模板.
主要方法:
- 使用动态组合库 (DCL).
- 使用模板导向合成形成分子复合物.
- 监测相对于临界聚合度 (CAC) 的分子聚合和度.
主要成果:
- 模板添加成功地增加了一个特定的图书馆成员模板复合体的CAC.
- 这种增加促使图书馆成员自我复制.
- 即使在删除模板后,自我复制的聚合物也继续形成.
结论:
- 模板可以作为DCL启动自我复制的催化剂.
- 克服CAC是自我复制的关键步骤.
- 自我复制,一旦启动,可以成为自我维持和模板独立.
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