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通过计算设计提高人工金属酶的催化性能

Tillmann Heinisch1, Michela Pellizzoni1, Marc Dürrenberger1

  • 1†Department of Chemistry, University of Basel, 4056 Basel, Switzerland.

Journal of the American Chemical Society
|July 31, 2015
PubMed
概括

计算设计优化了人工转移化酶 (ATHases),以改善非对称减排中的催化活性和酶选择性. 这种增强的酶设计导致了更高的 (S) - 沙索利丁的产量,这是一个关键的制药前体.

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