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使用结合聚合物菌株传感器监测蛋白质体组件

Hande E Cingil¹, Ingeborg M Storm¹, Yelda Yorulmaz¹

¹Physical Chemistry and Soft Matter, Wageningen University, Dreijenplein 6, 6703 HB Wageningen, The Netherlands.

Journal of the American Chemical Society

|August 1, 2015

概括

结合聚合物

科学领域:

光电子产品
聚合物科学
纳米技术

背景情况:

半导体聚合物具有光电子性质,因为它们的电子结构偏移.
聚合物形状显著影响光谱特征,机械拉伸导致振动变化.

研究的目的:

证明结合多电解质的光机学反应用于检测蛋白质囊封装.
通过测量由蛋白质涂层诱导的聚合物伸展来量化囊形成.

主要方法:

利用半导体聚合物对机械应变的灵敏度.
观察蛋白质封装时的聚合物固体阻碍和拉伸所导致的光谱变化.

主要成果:

结合的多电解质的蛋白质涂层诱导由于硬质阻碍的伸展.
聚合物链的机械平面化导致振动光谱的明显变化.
体形成过程可以通过这些光谱变化直接量化.

结论:

结合聚合物的光机械反应可以非侵入性地测量纳米级菌株.
这种方法可以检测和量化聚合物系统中的蛋白质封装.
聚合物中的振动状态和机械应力提供了一种新的传感机制.

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