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在低氧诱导因素中的结构整合

Dalei Wu1, Nalini Potluri1, Jingping Lu1

  • 1Metabolic Disease Program, Sanford Burnham Prebys Medical Discovery Institute, Orlando, Florida 32827, USA.

Nature
|August 7, 2015
PubMed
概括

低氧诱导因子 (HIF) 调节细胞适应低氧,促进瘤生长. 通过详细描述小分子结合点,对HIF-α-ARNT异构体的结构洞察力揭示了潜在的抗癌药物点.

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