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在ALS-FTD中,非保存的密码表子的TDP-43抑制受损

Jonathan P Ling1, Olga Pletnikova1, Juan C Troncoso2

  • 1Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD 21205-2196, USA.

Science (New York, N.Y.)
|August 8, 2015
PubMed
概括

通常情况下,TDP-43蛋白抑制了隐秘的外拼接. 细胞中TDP-43的丢失导致了隐秘的外基因包容,导致细胞死亡,这是ALS-FTD中发现的缺陷.

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