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儿童的脑水
Kristopher T Kahle1, Abhaya V Kulkarni2, David D Limbrick3
1Department of Neurosurgery, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Lancet (London, England)
|August 11, 2015
概括
一种影响脑室的脑脊液 (CSF) 疾病, 越来越多地被理解为超出了简单的阻塞. 不断发展的模型包括大脑脉动和水运输,
科学领域:
- 神经学
- 儿童医学
- 生理学
背景情况:
- 水脑是一种常见的疾病,其特征是由于脑脊液 (CSF) 生理学障碍而导致脑室异常膨胀.
- 婴儿通常出现大脑,而年龄较大的儿童则表现出脑内高血压的迹象.
- 目前的理解正在从纯粹阻塞模型转变为整合大脑脉动,大脑服从和水运输机制.
研究的目的:
- 提供关于水脑病理学的发展理解的概述.
- 讨论水头的各种原因,包括先天性和获得的形式.
- 突出目前和未来的治疗考虑因素及其对长期结果的影响.
主要方法:
- 目前关于脑水症病理学和治疗的文献综述.
- 分析包括大脑脉动,大脑服从和水运输在内的演变模型.
- 讨论先天性水头和获得形式的病理过程中的遗传联系.
主要成果:
- 水脑症的理解正在扩大到包括动态生理因素.
- 先天性水脑与调节大脑发育的基因有关; 获得的形式源于各种病理过程.
- 治疗涉及个性化的分流或内镜方法,结果各不相同.
结论:
- 了解脑水病理学的进展,包括大脑脉动和水运输,至关重要.
- 个性化治疗策略对于治疗儿童脑水症至关重要.
- 影像,技术和病理生理学研究的不断进步有望改善治疗方法和结果.
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