神经性斑点的前脊椎动物起源
Philip Barron Abitua1, T Blair Gainous1, Angela N Kaczmarczyk1
1Center for Integrative Genomics, Division of Genetics, Genomics and Development, Department of Molecular and Cell Biology, University of California, Berkeley, California 94720, USA.
Nature
|August 11, 2015
概括
研究人员在衣动物中发现了一种原体外皮,揭示了神经发生的保存发育途径. 这一发现揭示了脊椎动物感觉器官和"新头"的进化起源.
科学领域:
- 发育生物学
- 进化生物学
- 神经科学
背景情况:
- 对于脊椎动物头部发育至关重要的神经性斑点的进化起源尚不清楚.
- 状动物是脊椎动物的亲属, 提供了关于早期状动物进化的见解.
- 之前的研究表明原始的神经细胞在祖先的状动物.
研究的目的:
- 为了研究神经性斑点的进化起源.
- 确定早期状神经发生过程的保存.
- 了解脊椎动物感官器官发育的原始状态.
主要方法:
- 我研究了状肠子胚胎.
- 研究了骨基因蛋白 (BMP) 抑制的作用.
- 分析了像Six1/2和Eya这样的关键发育基因的表达.
- 来自原体外皮的特征神经元.
主要成果:
- 在Ciona intestinalis中发现了一种原皮外皮 (PPE).
- 证明个人防护设备的开发需要BMP抑制,并涉及Six1/2和Eya.
- 表明Ciona PPE会产生表达性腺激素释放激素 (GnRH),RXFP3和CNGA基因的毛神经元.
- 这些神经元具有潜在的化学传感和神经分泌功能.
结论:
- 肠虫具有神经原始斑块,表明其发育机制得到保护.
- 鉴定出的神经元可能与脊椎动物的嗅觉和下丘脑神经元有关.
- 这表明Ciona PPE衍生的GnRH神经元可能代表脊椎动物神经内分泌进化中至关重要的祖先细胞类型.
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