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Updated: Apr 5, 2026

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PIK3CA ((H1047R) 诱导多种强度和多种血统的乳腺瘤

Shany Koren1, Linsey Reavie1, Joana Pinto Couto1

  • 1Friedrich Miescher Institute for Biomedical Research (FMI), 4058 Basel, Switzerland.

Nature
|August 13, 2015
PubMed
概括

PIK3CA(H1047R) 突变可能导致乳腺细胞恢复到多能干状状态,从而导致异质瘤形成. 这种突变产生的细胞类型会影响瘤的恶性和攻击性.

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Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
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