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Updated: Apr 5, 2026

HOX Loci Focused CRISPR/sgRNA Library Screening Identifying Critical CTCF Boundaries
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CRISPR 逆转 CTCF 位点改变基因组拓和增强/促进功能

Ya Guo1, Quan Xu1, Daniele Canzio2

  • 1Center for Comparative Biomedicine, MOE Key Laboratory of Systems Biomedicine, Institute of Systems Biomedicine, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao Tong University (SJTU), Shanghai 200240, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, School of Medicine, SJTU, Shanghai 200240, China; Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (MOE), Bio-X Center, School of Life Sciences and Biotechnology, SJTU, Shanghai 200240, China.

Cell
|August 16, 2015
PubMed
概括

在哺乳动物基因组中,CTCF结合位点 (CBS) 的方向决定了DNA循环的形成. 这种定位通过控制3D基因组结构来影响基因表达.

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