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内共生起源和真核基因的差异性损失
Chuan Ku1, Shijulal Nelson-Sathi1, Mayo Roettger1
1Institute of Molecular Evolution, Heinrich-Heine University, 40225 Düsseldorf, Germany.
Nature
|August 20, 2015
概括
细胞和线粒体等真核细胞器的起源涉及细菌的偶发基因转移. 大多数真核生物的基因遗传是垂直的,持续横向基因转移的长期影响有限.
科学领域:
- 进化生物学
- 基因组学
- 细胞生物学
背景情况:
- 叶绿体和线粒体分别起源于内共生蓝菌和蛋白质菌.
- 这些有机体保留了 prokaryotic 生物化学,但已经减少了基因组,大多数蛋白质是由核基因编码的.
- 内共生理论表明,基因通过有机细胞祖先进入真核基因组,预测偶尔的基因流入.
研究的目的:
- 在真核生物中区分与内共生相关的偶发基因转移和持续的横向基因转移.
- 分析真核基因家族与原核基因同类的进化历史.
- 了解基因转移对真核基因组进化的长期影响.
主要方法:
- 对真核生物基因家族的聚类分析.
- 具有 prokaryotic 同类基因的真核基因家族的遗传学分析.
- 比较基因组学和基因分布分析.
主要成果:
- 从细菌转移到真核生物是偶发的,与质体和线粒体的起源相吻合.
- 细胞基因遗传主要是垂直的,基因丢失解释了稀疏的分布.
- 持续的横向基因转移在长期的真核基因组进化中起着有限的作用.
结论:
- 在真核生物中获得细菌基因的主要机制是内共生事件期间的插曲性转移.
- 垂直遗传和差异性基因损失是真核生物基因组内容的主要驱动因素.
- 持续的横向基因转移并没有显著影响长期的真核基因组进化.
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