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通过招募Hdac2以特别抑制IL-6来解决炎症需要Tet2

Qian Zhang1,2, Kai Zhao1, Qicong Shen2

  • 1National Key Laboratory of Medical Molecular Biology & Department of Immunology, Institute of Basic Medical Sciences, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100005, China.

Nature
|August 20, 2015
PubMed
概括

十一转位2 (Tet2) 蛋白在骨髓细胞炎症解消过程中积极抑制IL-6基因转录. 失去Tet2会导致IL-6的增加和对炎症状况的敏感性增加.

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