简单的相转移和水纳米颗粒的表面生物功能利用Janus DNA四面体纳米结构
Juan Li1,2,3, Cheng-Yi Hong1, Shu-Xian Wu1
1The Key Lab of Analysis and Detection Technology for Food Safety of the MOE and Fujian Province, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University , Fuzhou 350002, China.
Journal of the American Chemical Society
|August 25, 2015
概括
研究人员开发了一种使用DNA纳米结构修改疏水性纳米材料的通用方法. 这一战略增强了相位转移和表面生物功能,以改善生物医学应用.
科学领域:
- 生物医学工程
- 纳米技术
- 分子生物学
背景情况:
- 疏水性纳米粒子为生物分析和生物医学应用提供了显著的潜力.
- 它们的应用受到相位转移和表面修饰的挑战所限制.
研究的目的:
- 开发一种简单且通用的相移和疏水纳米材料表面生物功能化策略.
- 为了增强纳米材料的特性,利用apt-pend DNA四面体纳米结构 (Apt-tet).
主要方法:
- 使用修改后的DNA链和AS1411体构建了Janus DNA四面体纳米结构.
- 该AS1411的目标是瘤细胞过度表达的核素.
- 将Apt- tet和单链DNA的相传效率进行了比较.
主要成果:
- 与单链DNA相比,Apt-tet策略的相传效率显著更高.
- 纳入aptamer增强了准能力和纳米材料的细胞内吸收.
- DNA四面体纳米结构允许结合其他功能性核酸.
结论:
- 开发的Apt-tet策略为疏水性纳米材料的改造提供了一种通用方法.
- 这种方法改善了相位转移和生物功能,扩大了生物医学应用.
- 该战略可能为相转移剂和疏水纳米材料的利用建立一个新的范例.
相关概念视频
01:23RNA Structure
Overview
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
The basic structure of RNA consists of a five-carbon sugar and one of four nitrogenous bases. Although most RNA is single-stranded, it can form complex secondary and tertiary structures. Such structures play essential roles in the regulation of transcription and translation.
Different Types of RNA Have the Same Basic Structure
There are three main types of ribonucleic acid (RNA): messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). All three RNA types consist of a...
02:57DNA-only Transposons
DNA-only transposons are called autonomous transposons since they code for the enzyme transposase that is required for the transposition mechanism. Insertion of transposons can alter gene functions in multiple ways. They can mutate the gene, alter gene expression by introducing a novel promoter or insulator sequence, introduce new splice sites, and change the mRNA transcripts produced, or remodel chromatin structure.
The donor site from where the transposon is excised is either degraded or...
The donor site from where the transposon is excised is either degraded or...