祖父母的饮食是否会影响后代的体重和患下症的风险?
Thomas Chambers1, Amanda Drake2, Richard Sharpe1
1MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, UK.
Lancet (London, England)
|August 28, 2015
概括
祖父母的高脂肪饮食会对后代代代谢和生殖健康产生负面影响. 这表明人类肥胖流行病的原因比以前更广泛.
科学领域:
- 健康和疾病的表观遗传学和发育起源 (DOHaD).
- 代谢和生殖健康
背景情况:
- 自1980年以来,全球肥胖率翻了一番, 世界卫生组织 (WHO) 指出了可预防的原因.
- 虽然饮食和体育活动是公认的因素,但新出现的证据表明父母和祖父母的饮食习惯也可能起作用.
- 用高脂肪饮食 (HFD) 模型研究代际对健康的影响.
研究的目的:
- 研究祖父母高脂肪饮食对后代代代谢和生殖健康的影响.
- 探索与饮食有关的代际健康影响背后的潜在机制.
主要方法:
- 斯普拉格 - 达利大鼠被食HFD (45%脂肪) 或对照饮食 (10%脂肪) 14周 (F0代).
- F0大鼠是为了产生F1的后代而繁殖的,在繁殖以产生F2后代之前,它们被维持在对照饮食中.
- 在F0,F1和F2世代评估了新陈代谢和生殖参数,使用ANOVA和混合模型分析数据.
主要成果:
- 在HFD中,F0小鼠的体重增加和内脏脂肪增加.
- HFD母亲的F1后代和HFD父亲的F1女儿体重增加.
- 从母方HFD祖父的F2男性后代体重增加,内脏脂肪,血瘦素,以及变化的黄质激素与的比率.
- F2后代 (男性和女性) 的母亲祖父消费HFD显示胰岛素敏感性降低.
结论:
- 祖父母的HFD以性别和世代特定的方式显著影响两个后代的新陈代谢和生殖健康.
- 这些发现表明,目前人类肥胖的流行病可能比目前认可的更复杂.
- 需要进一步研究以阐明这些跨代效应背后的确切因果机制.
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