用于预防早产婴儿感染的局部软化剂:系统性审查
Jemma Cleminson1, William McGuire1
1University of York, York, UK.
Lancet (London, England)
|August 28, 2015
概括
局部软化剂不能预防早产婴儿的侵袭性感染或死亡. 建议在低收入国家的新生儿皮肤护理中进一步研究低成本的局部油.
科学领域:
- 新生儿皮肤病
- 预防传染病
- 基于证据的医学
背景情况:
- 预产婴儿的皮肤屏障不成熟, 增加感染风险.
- 局部软化剂可以增强皮肤完整性并预防感染.
- 侵袭性感染是早产婴儿死亡的主要原因.
研究的目的:
- 对局部软化剂用于预防早产婴儿侵袭性感染和死亡的证据进行系统审查.
主要方法:
- 随机对照试验的系统审查.
- 包括2809名早产婴儿的16项试验.
- 低收入国家与高收入国家的子组分析.
主要成果:
- 分析显示使用软化剂的感染率较高 (RR 1. 20).
- 没有观察到对死亡率或其他疾病的显著影响.
- 在低收入国家,局部用油没有显著影响感染或死亡率,但改善了体重和身高增加.
结论:
- 目前的数据缺乏强有力的证据证明软化剂可以预防早产婴儿的感染或死亡.
- 对于低收入家庭的新生儿护理, 需要对低成本的局部油进行进一步的大规模试验.
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