虫寄生虫在移植中获得免疫耐受性的作用
Chris Johnston1, Henry McSorley1, Danielle Smyth1
1University of Edinburgh, Edinburgh, UK.
Lancet (London, England)
|August 28, 2015
概括
在接受异种移植的小鼠中,Helminth寄生虫产品促进免疫耐受性,显著增加调节性T细胞和PD1表达. 这表明一种新的治疗方法可以预防移植拒绝.
科学领域:
- 免疫学
- 寄生虫学
- 移植科学
背景情况:
- 虫感染全球超过25%的人口, 调节宿主免疫反应.
- 这种免疫调节可以抑制有害的过敏和自身免疫反应.
- 这项研究研究了虫感染对异种移植免疫力的影响.
研究的目的:
- 测试虫感染会降低对移植的免疫反应的假设.
- 探索虫衍生的产品在调节移植免疫力的潜力.
主要方法:
- 在C57BL/ 6小鼠中,连续输注了Heligmosomoides polygyrus分泌的产物.
- 小鼠接受了来自BALB/c捐赠者的全异性皮肤移植.
- 通过流细胞测量分析了淋巴结排泄的淋巴细胞.
主要成果:
- 在接受治疗的小鼠中观察到CD4+CD25+Foxp3+调节T细胞的显著增加 (41. 7%).
- 调节性受体PD1的平均表达在 CD4 T 细胞中增加了62. 2%.
- 这些发现表明寄生虫产品诱导了调节性免疫机制.
结论:
- 虫衍生产品在异构移植过程中有效诱导调节性免疫机制.
- 了解这些机制可以为移植耐受性提供新的治疗策略.
- 这项研究为开发新型治疗方法开辟了道路,
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