在慢性阻塞性肺病中,神经呼吸驱动和限制运动的症状
Caroline Jolley1, Yuanming Luo2, Joerg Steier3
1Division of Asthma, Allergy and Lung Biology, King's College London School of Medicine, King's Health Partners, London, UK.
Lancet (London, England)
|August 28, 2015
概括
慢性阻塞性肺部疾病 (COPD) 患者在运动期间出现呼吸困难,与腿部疲劳限制患者相比,神经呼吸驱动力 (EMGdi%max) 较高. 这一发现有助于识别可能受益于针对肺机制的干预的患者.
科学领域:
- 肺部医学
- 运动生理学
- 呼吸机械学
背景情况:
- 慢性肺炎患者的运动能力受到呼吸困难和腿部疲劳的限制.
- 神经呼吸驱动 (EMGdi%max) 量化了呼吸肌肉负荷,与呼吸困难有关.
研究的目的:
- 测试COPD患者在运动结束时的EMGdi%max是否更高,而不是由于呼吸困难而导致的腿部疲劳.
- 在COPD患者中区分运动限制的原因.
主要方法:
- 在COPD患者的消耗性循环人体测量中测量EMGdi%max,呼吸量,VO2和VE/MVV.
- 使用食道导管进行EMGdi测量.
- 使用ANOVA评估因呼吸困难,腿部疲劳或两者而停止的组之间的差异.
主要成果:
- 在受呼吸困扰的患者中,运动结束时的EMGdi%max显著高于腿部疲劳 (44. 1%) 或两者 (74. 1%).
- 在运动结束呼吸,VO2或VE/MVV之间没有发现显著差异.
结论:
- 由于呼吸障碍导致的COPD患者的呼吸力达到接近最大的神经呼吸力.
- 在运动期间测量EMGdi%max可以通过改善周围肌肉训练来确定最佳的患者.
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