相关实验视频

Updated: Apr 4, 2026

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

Co-staining Blood Vessels and Nerve Fibers in Adipose Tissue

Published on: February 13, 2019

在体内,高皮质隔离血和脂肪组织血流之间的关联

Konstantinos Manolopoulos¹, Hafwen Thornhill², Jennifer Thomas²

¹Centre for Endocrinology, Diabetes and Metabolism, University of Birmingham, Birmingham, UK.

Lancet (London, England)

|August 28, 2015

概括

过高皮质醇会增加脂肪组织的血液流动 (ATBF),特别是在关节区域,这可能解释了库辛综合征中的脂肪再分配. 这种效果在摄入葡萄糖后得到增强.

科学领域:

内分泌学
代谢生理学
心血管健康

背景情况:

果形的脂肪分布与不良的心脏代谢健康有关.
高皮质醇症 (库辛综合征) 导致腹部脂肪积累和关节脂肪损失.
这种脂肪再分配的机制尚不清楚,但脂肪组织血流 (ATBF) 是一个关键因素.

研究的目的:

调查高皮质醇症是否导致腹部和大腿部ATBF差异.
探索ATBF和脂肪分布变化的关系.

主要方法:

六名健康的男性接受了随机双盲注射.
使用放射性洗技术测量了腹部和大腿部的ATBF.
测量是在禁食和食后状态 (75g葡萄糖) 中进行的.

主要成果:

在禁食和食后状态下,皮质过高显著增加了股骨ATBF (分别为p<0. 08和p=0. 046).
腹部ATBF也增加,但没有达到统计学意义.
增加的ATBF与腰部和部的比率有很强的负相关性 (p<0. 008).

结论:

高皮质醇症增加了ATBF,最显著的是在部部区域,特别是在食后.
这种特定于仓库的反应表明脂肪酸流量差异,可能解释与库辛综合征相关的脂肪分布.
葡萄糖皮质激素和胰岛素的相互作用可能在这些仓储特异性影响中起作用.

更多相关视频

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Assessment of Human Adipose Tissue Microvascular Function Using Videomicroscopy

Published on: September 29, 2017

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Author Spotlight: The Significance of Isolation, Culture, and Adipogenic Induction of SVF-Derived Preadipocytes from Mouse Perivascular Adipose Tissue

Published on: July 21, 2023

相关概念视频

Hypodermis

Hypodermis

The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...