第一次精神病发作中的大麻使用和耐药性:自然语言处理研究
Rashmi Patel1, Robin Wilson1, Richard Jackson2
1King's College London, Department of Psychosis Studies, Institute of Psychiatry, London, UK.
Lancet (London, England)
|August 28, 2015
概括
在第一发精神病中使用大麻是常见的,并与更多的住院患者有关. 这部分是因为它增加了所需的抗精神病药物的数量,
科学领域:
- 精神病学
- 临床心理学
- 神经科学
背景情况:
- 在患有第一发精神病 (FEP) 的人群中,大麻使用很普遍.
- 大麻使用与FEP的临床结果较差有关.
- 大麻使用对FEP抗精神病治疗反应的影响尚不清楚.
研究的目的:
- 研究大麻使用与FEP临床结果之间的关联.
- 确定抗精神病治疗耐药性是否介导大麻使用和FEP的不良结果之间的关系.
主要方法:
- 利用自然语言处理从伦敦南部的2026名FEP患者的临床记录中识别大麻使用情况.
- 收集有关人口统计,诊断,住院和抗精神病药物处方的数据.
- 使用多变量回归和调解分析来检查关联.
主要成果:
- 在FEP患者中,有46.3%的人在呈现时使用大麻.
- 大麻使用与5年多的住院,强制住院和住院日数增加有关.
- 增加抗精神病药物的使用部分调解了这些关联,表明治疗耐药性.
结论:
- 大多数FEP患者使用大麻,与更高的住院率相关.
- 大麻使用可能会降低传统抗精神病治疗的有效性.
- 减少该人口大麻使用的策略对于改善结果至关重要.
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