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  • 1Farr Institute of Health Informatics Research, University College London, London, UK.

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此摘要是机器生成的。

二型糖尿病显著增加了心血管疾病的风险,如周围动脉疾病和心力衰竭. 了解这些不同的关联对于有效的糖尿病管理和临床试验至关重要.

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科学领域:

  • 心血管医学
  • 内分泌学
  • 公共卫生

背景情况:

  • 二型糖尿病与许多心血管疾病有关, 但缺乏全面的比较.
  • 之前的研究主要集中在心肌梗塞和中风.
  • 其他疾病如心力衰竭和胸痛是糖尿病发病的重要原因.

研究的目的:

  • 研究2型糖尿病与12种不同初始心血管疾病的相关性.
  • 在2型糖尿病患者中比较各种心血管结果的风险.

主要方法:

  • 使用CALIBER计划 (1997-2010年) 的链接电子健康记录.
  • 分析了192万名30岁以上的英格兰患者,在基线时没有心血管疾病.
  • 已注册的研究 (临床试验网站,NCT01804439).

主要成果:

  • 观察到超过113,000例心血管疾病,平均随访时间为5. 5年.
  • 2型糖尿病与周围动脉疾病 (HR 2. 98),缺血性中风 (HR 1. 72),稳定性心痛 (HR 1. 62),心力衰竭 (HR 1.56) 和非致命性心肌梗塞 (HR 1.54) 有着强烈的积极关联.
  • 发现与腹腔大动脉动脉瘤 (HR 0. 46) 和下关节出血 (HR 0. 48) 的反向关联.

结论:

  • 二型糖尿病与心血管疾病之间的关联是多种多样的.
  • 这些发现对2型糖尿病患者的临床风险评估产生影响.
  • 结果为2型糖尿病临床试验中选择主要终点提供了信息.