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使用18F-氧糖PET-CT和MRI评估患有活跃类风湿性关节炎的患者的状斑炎:试点研究

Sarah Skeoch¹, Heather Williams², Penny Cristinacce²

¹Arthritis Research UK Centre for Epidemiology, Centre for Musculoskeletal Research, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK; NIHR Manchester Musculoskeletal Biomedical Research Unit, University of Manchester, Manchester, UK.

Lancet (London, England)

|August 28, 2015

概括

患有类风湿性关节炎的患者表现出动脉斑块的炎症,与C反应性蛋白水平相关. 这表明关节和斑块炎症之间存在潜在联系,影响RA患者的心血管风险.

科学领域:

心血管医学
关节病学
医学成像

背景情况:

风湿性关节炎 (RA) 显著增加了50%的心血管死亡风险.
炎症可能加快动脉样硬化并促进易破裂的斑块表型.
这项研究研究了活跃的RA患者的带斑炎及其与炎症标志物的相关性.

研究的目的:

测试活性类风湿性关节炎患者表现出动脉斑炎的假设.
确定心血管斑块炎症是否与RA患者的临床和血清性炎症标志物相关.
探索CD4+CD28- T细胞在RA心血管风险预测中的潜在作用.

主要方法:

13名活跃的 RA 患者 (DAS28 > 3. 2) 接受了喉磁力共振成像和 (18) F- FDG PET- CT.
使用标准化最大吸收值 (SUV) 评估了心血管斑块炎症.
分析了SUV,DAS28,C反应蛋白和CD4+CD28- T细胞频率之间的关联.

主要成果:

所有13名患者都表现出鼻斑炎 (SUV) > 1. 6).
斑块炎症 (SUV) 与C反应蛋白 (r=0. 58, p=0. 04) 和CD4+CD28- T细胞频率 (p=0. 045) 显著相关.
没有发现与DAS28得分,LDL,年龄或性别的显著关联.

结论:

在活跃的 RA 患者中,状腺斑炎很常见,与 C- 反应蛋白相关.
这些发现表明,关节炎与斑块炎症之间存在潜在的联系.
CD4+CD28- T细胞可能在RA患者的心血管风险预测中发挥作用,因此需要进一步调查.

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