鼻癌
Melvin L K Chua1, Joseph T S Wee1, Edwin P Hui2
1Division of Radiation Oncology, National Cancer Centre Singapore, Singapore; Duke-NUS, Graduate Medical School, Singapore.
Lancet (London, England)
|September 1, 2015
概括
由于查,放射治疗和全身治疗的改善,鼻癌的死亡率正在下降. 爱斯坦-巴尔病毒 (EBV) DNA是查和监测这种癌症的关键生物标志物.
科学领域:
- 癌症学
- 流行病学
- 病毒学
背景情况:
- 全球鼻癌 (NPC) 发病率正在下降,但死亡率已显著下降.
- 医疗技术和治疗方式的进步有助于改善患者的治疗结果.
研究的目的:
- 审查鼻癌管理的流行病学趋势和进展.
- 突出埃普斯坦-巴尔病毒 (EBV) 作为NPC生物标志物的作用.
- 讨论转移性NPC的新兴疗法.
主要方法:
- 对NPC发生率和死亡率的流行病学数据的分析.
- 审查放射治疗,全身药物和生物标志物应用的最新进展.
- 对正在进行的新型NPC治疗临床试验进行审查.
主要成果:
- 由于生活方式的改变,强化查,高级放射治疗 (强度调节放射治疗) 和全身疗法,观察到NPC死亡率的显著降低.
- 循环埃普斯坦-巴尔病毒 (EBV) DNA 的定量评估越来越多地用于NPC查,预后和监测.
- 随机试验正在探索EBV DNA在调整治疗强度中的作用.
结论:
- 改进的治疗策略,包括先进的放射治疗和基于EBV的生物标志物,大大降低了鼻癌的死亡率.
- 像VEGF抑制和免疫疗法这样的新兴疗法对转移性疾病有希望.
- 对EBV的作用和新型治疗方法的持续研究对于进一步改善NPC患者的结果至关重要.
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