血压控制与脑内出血复发风险之间的关联
Alessandro Biffi1, Christopher D Anderson1, Thomas W K Battey1
1Center for Human Genetic Research, Massachusetts General Hospital, Boston2J. Philip Kistler Stroke Research Center, Massachusetts General Hospital, Boston3Division of Neurocritical Care and Emergency Neurology, Department of Neurology, Massachusetts Gener.
JAMA
|September 2, 2015
概括
在脑内出血 (ICH) 后血压控制不佳显著增加了ICH复发的风险. 维持足够的血压对于预防幸存者的进一步出血性中风至关重要.
科学领域:
- 神经学
- 心血管医学
- 公共卫生
背景情况:
- 脑内出血 (ICH) 是一种严重的中风,复发率很高.
- 患有ICH的患者面临死亡和功能衰退的重大风险.
研究的目的:
- 研究ICH后血压 (BP) 与ICH复发风险之间的关系.
- 研究血压控制如何影响后续出血性中风的可能性.
主要方法:
- 一项对1145名ICH幸存者进行的观察研究,平均持续36. 8个月.
- 定期监测血压,并根据既定的指导方针进行分类.
- 记录了反复发生的ICH事件及其位置 (叶片与非叶片).
主要成果:
- 不充分的血压控制与叶状和非叶状ICH复发的风险相连.
- 血压控制不足的患者的事件发生率是适当控制患者的1. 7至2. 4倍.
- 随访期间心压和腹压升高与复发风险增加有关.
结论:
- 在ICH后血压管理不足与复发的风险增加有关.
- 这些发现凸显了临床试验的必要性,以确定ICH幸存者的最佳血压目标.
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