中性粒细胞在呼吸道中引导流感特异性CD8+T细胞
Kihong Lim1, Young-Min Hyun1, Kris Lambert-Emo1
1Department of Microbiology and Immunology, David H. Smith Center for Vaccine Biology and Immunology, University of Rochester, Rochester, NY, USA.
Science (New York, N.Y.)
|September 5, 2015
概括
在流感感染期间,中性粒细胞会产生用于招募CD8 ((+) T细胞的化学痕. 这些中性粒细胞沉积的痕迹引导T细胞到感染部位,增强免疫保护.
科学领域:
- 免疫学
- 病毒学
- 细胞生物学
背景情况:
- 在病毒感染期间,化学因子对于将T细胞引导到感染部位至关重要.
- 产生这些化学因子的特定细胞及其招募T细胞的机制在很大程度上尚不清楚.
研究的目的:
- 调查中性粒细胞在流感病毒感染期间的化学因子产生和T细胞招募中的作用.
- 阐明中性粒细胞对CD8 ((+) T细胞介导的免疫保护所起作用的机制.
主要方法:
- 使用流感感染的小鼠模型.
- 使用颗粒细胞特异性CXCL12条件耗尽.
- 用CXCR4抗剂来评估化学激素途径的参与.
主要成果:
- 早期对流感感染的气管中的中性粒细胞的招募对于CD8(+) T细胞介导的免疫是至关重要的.
- 迁移中的中性粒细胞沉积了富含化学基因CXCL12的持续性痕迹.
- 来自中性粒细胞的CXCL12对于招募病毒特异性CD8 ((+) T细胞和支持它们的效应器功能至关重要.
结论:
- 中性粒细胞在受感染的组织中沉积长期的化学痕 (CXCL12).
- 这些中性粒细胞痕迹为CD8 ((+) T细胞迁移和局部化提供了必不可少的化学和触觉信号.
- 中性粒细胞通过指导T细胞对流感的适应性免疫反应起着关键作用.
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