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Updated: Apr 4, 2026

Generation of Alpha-Synuclein Preformed Fibrils from Monomers and Use In Vivo
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Published on: June 2, 2019

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来自隐形晶体的α-synuclein有毒核心的结构

Jose A Rodriguez1, Magdalena I Ivanova1, Michael R Sawaya1

  • 1Howard Hughes Medical Institute, UCLA-DOE Institute, Departments of Biological Chemistry and Chemistry and Biochemistry, Box 951570, UCLA, Los Angeles, California 90095-1570, USA.

Nature
|September 10, 2015
PubMed
概括

研究人员使用微电子衍射确定了帕金森病关键蛋白质部分NACore的原子结构. 这一突破揭示了有毒纤维细胞的形成和潜在的治疗点.

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Atomic Scale Structural Studies of Macromolecular Assemblies by Solid-state Nuclear Magnetic Resonance Spectroscopy

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