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Updated: Mar 27, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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对β-catenin/B细胞淋巴瘤9蛋白与蛋白相互作用的选择性小分子抑制剂的合理设计

Logan R Hoggard1, Yongqiang Zhang1, Min Zhang1

  • 1Department of Chemistry, Center for Cell and Genome Science, University of Utah , Salt Lake City, Utah 84112-0850, United States.

Journal of the American Chemical Society
|September 10, 2015
PubMed
概括

研究人员设计了小型有机分子来选择性地抑制α-螺旋蛋白-蛋白相互作用 (PPI). 这些新型抑制剂向β-catenin/BCL9相互作用,为癌症治疗提供了潜力.

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