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子宫内膜癌

Philippe Morice¹, Alexandra Leary², Carien Creutzberg³

¹Department of Gynecologic Surgery, Gustave Roussy, Villejuif, France; Unit INSERM U 1030, Gustave Roussy, Villejuif, France; Université Paris-Sud (Paris XI), Le Kremlin Bicêtre, France.

Lancet (London, England)

|September 11, 2015

概括

子宫内膜癌,主要是子宫内膜腺癌,越来越多地被早期诊断出来. 标准治疗包括切除子宫,并根据患者和病因量身定制的手术和辅助疗法以实现最佳生存.

科学领域:

妇科瘤学
外科瘤学
病理学

背景情况:

在发达国家, 子宫内膜癌是最常见的妇科恶性瘤,
最常见的是子宫内膜腺癌亚型,通常在早期被诊断为子宫内.

研究的目的:

概述目前对子宫内膜癌的标准治疗策略.
讨论影响手术决定和辅助治疗选择的因素.
审查高风险患者的预后指标和正在进行的研究.

主要方法:

主要治疗包括双侧切除术,通常采用微创手术技术.
淋巴结管理是根据组织学特征,疾病阶段,患者特征和临床指导方针进行的.
辅助治疗是根据瘤组织学和阶段进行的,以控制复发风险.

主要成果:

在没有转移性疾病的患者中,五年整体存活率为74%至91%.
风险分层系统有助于确定术后管理和预测复发.
目前正在进行的临床试验正在评估新型辅助疗法,如化疗,化疗辐射和针对高危人群的向疗法.

结论:

目前对子宫内膜癌的治疗是通过针对性辅助策略平衡手术干预的.
个性化治疗方法旨在优化生存结果,同时尽量减少对生活质量的不良影响.
进一步的研究对高风险子宫内膜癌患者的治疗方案至关重要.

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