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Updated: Apr 3, 2026

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在白血病干细胞中出现BET抑制剂耐药性

Chun Yew Fong1,2,3, Omer Gilan1,2, Enid Y N Lam1

  • 1Cancer Research Division, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia.

Nature
|September 15, 2015
PubMed
概括

在急性髓性白血病中,代蛋白和额外终端蛋白 (BET) 抑制剂具有前景. 从白血病干细胞中产生耐药性,部分原因是Wnt/β-catenin信号的增加,这种信号可以被向恢复药物敏感性.

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