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转录性可塑性促进了对BET抑制的初级和获得性耐药性

Philipp Rathert1, Mareike Roth1, Tobias Neumann1

  • 1Research Institute of Molecular Pathology (IMP), Vienna Biocenter (VBC), 1030 Vienna, Austria.

Nature
|September 15, 2015
PubMed
概括

通过恢复MYC转录,WNT信号驱动急性髓性白血病 (AML) 中的BET抑制剂的耐药性. 这一发现确定WNT是克服AML治疗耐药性的关键生物标志物和治疗标.

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