喘的危险因素:预防可能吗?
Richard Beasley1, Alex Semprini1, Edwin A Mitchell2
1Medical Research Institute of New Zealand, Wellington, New Zealand.
Lancet (London, England)
|September 19, 2015
概括
喘仍然是一个重要的全球健康挑战, 进一步研究致病因素对于制定有效的初级预防策略来减少这种慢性呼吸道疾病的全球负担至关重要.
科学领域:
- 公共卫生
- 流行病学
- 呼吸系统医学
背景情况:
- 喘是一种普遍的全球性疾病,
- 虽然喘死亡率有所下降,但喘患病率的增加仍是整体负担.
- 喘患病率上升的根本原因在很大程度上仍未明确,
研究的目的:
- 强调迫切需要更好地了解喘病因.
- 强调开发新的初级预防策略和研究方法的必要性.
- 引导旨在改善肺部和整体健康的临时公共卫生措施.
主要方法:
- 对喘风险因素和初级预防研究的现有文献的审查.
- 从观察性研究中证明因果关系的挑战分析.
- 评估初级预防干预的随机对照试验的证据.
主要成果:
- 许多报告的喘风险因素的因果关系很难从观察数据中确定.
- 现有的初级预防策略缺乏足够的证据来广泛的临床实施.
- 目前的认识限制了针对性初级预防措施的发展.
结论:
- 对于有效的公共卫生和药物预防, 更深入地了解喘的病因因素至关重要.
- 需要创新的方法来识别风险因素和制定预防策略.
- 临时公共卫生工作应集中在促进一般和呼吸系统健康的已确立措施上.
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