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登革热病毒在抗原上聚集,但不是分立的血清型

Leah C Katzelnick¹, Judith M Fonville², Gregory D Gromowski³

¹Center for Pathogen Evolution, Department of Zoology, University of Cambridge, Downing Street, Cambridge CB2 3EJ, UK. World Health Organization (WHO) Collaborating Center for Modeling, Evolution, and Control of Emerging Infectious Diseases, Cambridge CB2 3EJ, UK. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, CA 94720-3370, USA.

Science (New York, N.Y.)

|September 19, 2015

概括

登革热病毒 (DENV) 的类型在抗原上不均. 这种抗原多样性影响疾病动态,疫苗有效性和病毒演变,需要对DENV研究和控制采取细微的方法.

科学领域:

病毒学
免疫学
流行病学

背景情况:

登革热病毒 (DENV) 包含四种基因上不同的类型,传统上被归类为血清型.
DENV类型之间的抗原和遗传变异显著影响疾病严重程度,疫苗有效性,流行病潜力和病毒演变.

研究的目的:

描述四种DENV类型中的抗原多样性.
研究抗原异质性对免疫力,疾病动态和DENV演变的影响.

主要方法:

使用中和抗体标位构建抗原图.
对非洲绿的抗体反应,人类疫苗接种和自然感染的分析.
不同DENV分离物之间的抗原关系的比较.

主要成果:

不同的DENV隔离物显示出类型的松散聚类,但类型之间具有显著的抗原重叠.
在DENV类型中,即使在同类型中,初级感染抗血清在感染后的两年内也表现出有限的交叉中和.
发现正规DENV类型具有抗原异质性.

结论:

传统的DENV类型的抗原均分类是不准确的.
抗原多样性对登革热疫苗的研发以及对免疫力,疾病进展和病毒演变的理解具有重要意义.
需要进一步的研究来解决DENV抗原变异的复杂性.

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