模块化合成平台用于构建功能单链聚合物纳米粒子:从水性催化到光敏化
Yiliu Liu1, Thomas Pauloehrl1, Stanislav I Presolski1
1Institute for Complex Molecular Systems, Laboratory of Macromolecular and Organic Chemistry, Eindhoven University of Technology , P.O. Box 513, 5600 MB, Eindhoven, The Netherlands.
Journal of the American Chemical Society
|September 22, 2015
概括
研究人员开发了一种多功能方法,用于催化和光动力学治疗的功能单链聚合物纳米粒子 (SCPN). 这种模块化平台可以控制活性单元的放置,从而实现高效的生物直角催化和药物输送应用.
科学领域:
- 聚合物化学
- 纳米技术
- 超分子化学
- 催化剂
- 光动力疗法
背景情况:
- 单链聚合物纳米粒子 (SCPN) 具有多种应用的潜力,但需要控制的合成策略.
- 开发用于在聚合物骨干上随机但可控的功能组定位的方法对于SCPN设计至关重要.
- 现有的合成途径可能无法提供创建多功能SCPN所需的多功能性.
研究的目的:
- 为合成功能性SCPNs提出一个一般的后聚合修饰策略.
- 通过创建用于生物直角催化和光动力学治疗的SCPN来证明平台的模块化.
- 能够快速和可控地访问具有可调节功能的SCPN.
主要方法:
- 使用序列添加氨基的聚甲烯酸 (pPFPA) 的后聚合修饰.
- 将超分子识别基因 (-1,3,5-三胺) 和聚乙 (杰法) 纳入水中的SCPN以形成共聚物和自我组装.
- 用金属结合体 (Bimpy,Phen,BiPy) 进行催化和氨酸用于光动力学治疗,包括用于药物输送的 (1) O2可切割结合剂.
主要成果:
- 在水溶液中成功合成可折叠成SCPN的随机共聚物.
- 能够在生理条件下催化生物直角反应 (酸循环添加与Cu(I),脱化与Pd(II) 的SCPNs.
- 创建了作为单片氧生成光敏剂的SCPN,并演示了光触发药物模型释放的级联系统.
结论:
- 提出的模块化合成策略提供了一种通用和快速的方法来访问功能性SCPN.
- 开发的SCPN具有可调性特性,可用于催化和光动力疗法.
- 这种方法有助于控制各种功能单元的结合,以实现先进的材料设计.
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