从科学发现到治疗:星系中的明亮星星
R Sanders Williams1, Samad Lotia2, Alisha K Holloway1
1Gladstone Institutes, San Francisco, CA 94158, USA; University of California, San Francisco, San Francisco, CA 94143, USA.
Cell
|September 26, 2015
概括
数据挖掘和公共数据库的网络分析可以揭示科学发现与医疗疗法之间的联系. 这些方法可以促进公众对生命科学研究的支持,并改善寻找治疗方法的决策.
科学领域:
- 生物医学信息学
- 转化医学
- 科学发现分析
背景情况:
- 了解基础研究与临床突破之间的联系对于医学进步至关重要.
- 现有的追踪科学影响的方法往往缺乏定量严格性.
- 公共数据库提供了丰富的相互联系的科学数据来源.
研究的目的:
- 提出和概述使用数据挖掘和网络分析来绘制科学发现和医学治疗之间的关系的方法.
- 突出这些计算方法在推进医学研究和公众参与方面的潜力.
- 展示定量分析如何为生命科学中的战略决策提供信息.
主要方法:
- 使用数据挖掘技术从公共科学数据库中提取相关信息.
- 使用网络分析可视化和量化不同研究结果之间的联系.
- 开发计算框架以确定将基本发现与治疗结果联系在一起的模式.
主要成果:
- 提出的方法可以系统地识别和量化科学发现与重大医学进展 (治疗) 之间的关系.
- 网络分析提供了科学环境的可视化和可量化的表现.
- 数据挖掘可以揭示从基础科学到临床应用之前未知的途径.
结论:
- 数据挖掘和网络分析为了解医学研究的进展提供了强大的工具.
- 这些计算方法可以通过展示影响来增强公共和政府对生命科学研究的支持.
- 这些方法的进一步发展可以在寻找治疗方法的决策中显著帮助.
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