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Obesity01:24

Obesity

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The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.5K
Overview of Lipid Metabolism01:24

Overview of Lipid Metabolism

6.8K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
6.8K
Regulation of Food Intake01:30

Regulation of Food Intake

3.2K
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
3.2K
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

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Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
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Fats as Energy Storage Molecules01:06

Fats as Energy Storage Molecules

7.3K
7.3K
Hypodermis01:02

Hypodermis

8.6K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
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相关实验视频

Updated: Apr 3, 2026

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro
09:41

Measuring the Rate of Lipolysis in Ex Vivo Murine Adipose Tissue and Primary Preadipocytes Differentiated In Vitro

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一个对瘦素脂肪的同情的观点

Luis Varela1, Tamas L Horvath1

  • 1Program in Integrative Cell Signalling and Neurobiology of Metabolism, Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA.

Cell
|September 26, 2015
PubMed
概括

莱普的使用

科学领域:

  • 内分泌学
  • 神经科学
  • 脂肪组织生物学

背景情况:

  • 瘦素是调节能量平衡和体重的关键激素.
  • 瘦素耐药性是肥胖的一个标志,影响其代谢效应.
  • 精确的调解瘦素脂解作用的机制仍在研究中.

研究的目的:

  • 调查直接的神经通道调解瘦素对白脂肪细胞的脂解作用.
  • 探索针对本地同情输入来克服中枢抗素的潜力.

主要方法:

  • 使用先进的成像技术可视化交感神经纤维内化白色脂肪细胞.
  • 使用药理和遗传工具来操纵脂肪组织中的同情活性.

主要成果:

  • 证明了同情神经纤维直接覆盖了白色脂肪细胞.
  • 表明局部同情激活模仿并调解了勒的脂解作用.
  • 发现一个直接的神经回路将瘦素信号连接到脂肪组织.

结论:

  • 交感神经纤维是瘦素脂解作用的关键介质.
  • 通过绕过中枢勒素抵抗,针对脂肪组织的局部同情性内化提供了一种新的策略来对抗肥胖.

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