临床前小鼠癌症模型:一个机会和挑战的迷宫
Chi-Ping Day1, Glenn Merlino1, Terry Van Dyke2
1Laboratory of Cancer Biology and Genetics, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA.
Cell
|September 26, 2015
概括
大多数新的癌症药物由于效率低下而失败,因为目前的临床前模型无法充分预测成功. 本综述考察了先进的小鼠癌症模型和用于更好的临床前药物评估的新兴策略.
科学领域:
- 癌症学
- 翻译医学
- 药物开发
背景情况:
- 针对癌症的向疗法已经显示出前途,
- 然而,大多数新型癌症药物在临床试验中失败,主要是由于缺乏疗效.
- 这种高失败率凸显了当前临床前评估方法的局限性.
研究的目的:
- 审查先进小鼠癌症模型临床前评估的现状,前景和挑战.
- 讨论现有的临床前方法在预测临床疗效方面的局限性.
- 简要介绍早期临床前发展的新兴模型.
主要方法:
- 在临床前药物评估中使用的晚期小鼠癌症模型的探索.
- 分析导致癌症候选药物失败的因素.
- 简要介绍新型和新兴的临床前模型.
主要成果:
- 目前的临床前方法,特别是使用先进小鼠模型的方法,在准确预测新型癌症疗法的方面存在局限性.
- 新型癌症药物的低批准率强调了需要改进的临床前评估策略.
- 新兴的模型显示了增强早期临床前发展和预测治疗结果的潜力.
结论:
- 改善临床前评估策略至关重要, 以提高新型癌症药物开发的成功率.
- 先进的小鼠癌症模型提供了有价值的见解,但需要进一步细化以更好地预测临床结果.
- 新兴的临床前模型可以提供更准确的预测,通过加快有效的癌症治疗方法的开发,有可能降低财务成本并改善患者的生活质量.
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