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Updated: Jun 17, 2026

DNA Methylation: Bisulphite Modification and Analysis
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DNA Methylation: Bisulphite Modification and Analysis

Published on: October 21, 2011

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在单细胞分辨率下追踪DNA甲基化的动态变化

Yonatan Stelzer1, Chikdu Shakti Shivalila2, Frank Soldner1

  • 1Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Cell
|September 26, 2015
PubMed
概括

研究人员开发了一个基因组甲基化报告器 (RGM) 来跟踪动态DNA变化. 这种工具可实时可视化甲基化状态, 提供对发育和疾病的新见解.

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Immunostaining for DNA Modifications: Computational Analysis of Confocal Images

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Rapid and Efficient Spatiotemporal Monitoring of Normal and Aberrant Cytosine Methylation within Intact Zebrafish Embryos

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相关概念视频

Protein Dynamics in Living Cells01:19

Protein Dynamics in Living Cells

Different fluorescence-based techniques are used to study the protein dynamics in living cells. These techniques include FRAP, FRET, and PET.
Fluorescent recovery after photobleaching (FRAP) is a fluorescent-protein-based detection technique used to quantify protein movement rates within the cell. This method exposes a small portion of the cell to an intense laser beam. The laser beam causes permanent photobleaching of the fluorophore-tagged proteins in the exposed region. As the bleached...