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Updated: Apr 1, 2026

Substrate Generation for Endonucleases of CRISPR/Cas Systems
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Published on: September 8, 2012

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Cpf1是一个单一的RNA导向内核酶,属于2类CRISPR-Cas系统

Bernd Zetsche1, Jonathan S Gootenberg2, Omar O Abudayyeh3

  • 1Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Developmental Pathology, Institute of Pathology, Bonn Medical School, Sigmund Freud Street 25, 53127 Bonn, Germany.

Cell
|October 1, 2015
PubMed
概括

研究人员发现了Cpf1,一种新型的CRISPR- Cas效应蛋白. 这种RNA引导的内核酶提供了独特的DNA分裂机制,并显示了人类细胞中的高效基因组编辑,扩展了CRISPR技术.

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