扭转动脉动症和硬化症的发生. 动脉样硬化的两个组成部分
1Atherosclerosis Research Institute, University of Southern California, School of Medicine, Los Angeles 90024.
Circulation
|January 1, 1989
概括
动脉样硬化,以脂肪沉积和血管硬为特征,在动物模型中是可逆的,在人类中显示出逆转的潜力. 未来的研究应该评估这两个组成部分,以全面了解损伤逆转.
科学领域:
- 心血管研究研究心血管研究
- 病理学 病理学 病理学
- 医学科学 医学科学 医学科学
背景情况:
- 动脉样硬化,在1904年描述,涉及脂肪退化和血管硬化.
- 目前的研究主要集中在脂质成分 (动脉动脉症),但血管硬化 (硬化) 也起着作用.
- 动脉动症和硬化症都越来越多地被认为是疾病的潜在可逆方面.
研究的目的:
- 审查动脉样硬化中动脉样和硬化两种疾病的可逆性证据.
- 突出两个组成部分在病变发展和潜在逆转中的作用.
- 为未来动脉样硬化逆转研究提出全面的评估方法.
主要方法:
- 审查关于动脉样硬化逆转现有的动物研究数据.
- 对人类血管学试验的分析,包括股骨和冠状动脉研究.
- 检查与硬化相关的血管变化的非侵入性测量.
主要成果:
- 动脉瘤的逆转在多种动物物种中得到了充分证据.
- 人体血管学试验表明病变稳定和潜在的逆转,特别是在CLAS试验中.
- 硬化症虽然微妙,但是由高胆固醇饮食引起的,在灵长类动物中,饮食戒断后可逆.
结论:
- 动脉样硬化的脂质 (动脉样硬化) 和纤维 (硬化) 组成部分都显示出可逆性.
- 动脉样硬化的逆转可能涉及内皮衍生的放松因子 (EDRF).
- 对动脉样硬化和动脉样硬化进行全面的评估对于未来关于动脉样硬化逆转的研究至关重要.
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